Comparative studies on tat mutants of three primate lentiviruses
Identifieur interne : 001529 ( Main/Exploration ); précédent : 001528; suivant : 001530Comparative studies on tat mutants of three primate lentiviruses
Auteurs : R. Shibata [Japon] ; H. Sakai [Japon] ; K. Ogawa [Japon] ; A. Ishimoto [Japon] ; A. Adachi [Japon]Source :
- Archives of Virology [ 0304-8608 ] ; 1990-09-01.
English descriptors
- KwdEn :
- Cells transfected, Clone, Culture fluids, Gene expression, Human immunodeficiency virus, Human immunodeficiency virus type, Human virus type, Immunodeficiency, Long terminal, Mutant, Negative control, Pnlabm, Primate, Primate lentiviruses, Proc natl acad, Proviral clones, Retrovirus, Shibata, Simian, Simian immunodeficiency virus, Sivagm, Transfected, Transfection, Viral, Viral gene expression, Virol, Wild type, Wild types.
- Teeft :
- Cells transfected, Clone, Culture fluids, Gene expression, Human immunodeficiency virus, Human immunodeficiency virus type, Human virus type, Immunodeficiency, Long terminal, Mutant, Negative control, Pnlabm, Primate, Primate lentiviruses, Proc natl acad, Proviral clones, Retrovirus, Shibata, Simian, Simian immunodeficiency virus, Sivagm, Transfected, Transfection, Viral, Viral gene expression, Virol, Wild type, Wild types.
Abstract
Summary: A frame-shifttat gene mutant of human immunodeficiency virus type 1 (HIV-1), which showed no detectable trans-activation potential, was constructed in vitro. Upon transfection, this clone directed the synthesis of virus mRNAs,gag proteins and virion-associated reverse transcriptase (RT) at a low level as was observed with thetat mutants of HIV-2 and simian immunodeficiency virus isolated from African green monkey (SIVAGM). Using these mutant viruses, trans-activation efficiency of viral gene expression bytat was compared among HIV-1, HIV-2, and SIVAGM. SIVAGM seemed to be less dependent ontat for RT production than HIV-1 and HIV-2.
Url:
DOI: 10.1007/BF01310753
Affiliations:
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Adachi</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Gene Analysis, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="abbrev">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1990-09-01">1990-09-01</date><biblScope unit="volume">114</biblScope><biblScope unit="issue">3-4</biblScope><biblScope unit="page" from="243">243</biblScope><biblScope unit="page" to="250">250</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cells transfected</term><term>Clone</term><term>Culture fluids</term><term>Gene expression</term><term>Human immunodeficiency virus</term><term>Human immunodeficiency virus type</term><term>Human virus type</term><term>Immunodeficiency</term><term>Long terminal</term><term>Mutant</term><term>Negative control</term><term>Pnlabm</term><term>Primate</term><term>Primate lentiviruses</term><term>Proc natl acad</term><term>Proviral clones</term><term>Retrovirus</term><term>Shibata</term><term>Simian</term><term>Simian immunodeficiency virus</term><term>Sivagm</term><term>Transfected</term><term>Transfection</term><term>Viral</term><term>Viral gene expression</term><term>Virol</term><term>Wild type</term><term>Wild types</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Cells transfected</term><term>Clone</term><term>Culture fluids</term><term>Gene expression</term><term>Human immunodeficiency virus</term><term>Human immunodeficiency virus type</term><term>Human virus type</term><term>Immunodeficiency</term><term>Long terminal</term><term>Mutant</term><term>Negative control</term><term>Pnlabm</term><term>Primate</term><term>Primate lentiviruses</term><term>Proc natl acad</term><term>Proviral clones</term><term>Retrovirus</term><term>Shibata</term><term>Simian</term><term>Simian immunodeficiency virus</term><term>Sivagm</term><term>Transfected</term><term>Transfection</term><term>Viral</term><term>Viral gene expression</term><term>Virol</term><term>Wild type</term><term>Wild types</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: A frame-shifttat gene mutant of human immunodeficiency virus type 1 (HIV-1), which showed no detectable trans-activation potential, was constructed in vitro. Upon transfection, this clone directed the synthesis of virus mRNAs,gag proteins and virion-associated reverse transcriptase (RT) at a low level as was observed with thetat mutants of HIV-2 and simian immunodeficiency virus isolated from African green monkey (SIVAGM). Using these mutant viruses, trans-activation efficiency of viral gene expression bytat was compared among HIV-1, HIV-2, and SIVAGM. SIVAGM seemed to be less dependent ontat for RT production than HIV-1 and HIV-2.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région du Kansai</li></region><settlement><li>Kyoto</li></settlement><orgName><li>Université de Kyoto</li></orgName></list><tree><country name="Japon"><region name="Région du Kansai"><name sortKey="Shibata, R" sort="Shibata, R" uniqKey="Shibata R" first="R." last="Shibata">R. Shibata</name></region><name sortKey="Adachi, A" sort="Adachi, A" uniqKey="Adachi A" first="A." last="Adachi">A. Adachi</name><name sortKey="Ishimoto, A" sort="Ishimoto, A" uniqKey="Ishimoto A" first="A." last="Ishimoto">A. Ishimoto</name><name sortKey="Ogawa, K" sort="Ogawa, K" uniqKey="Ogawa K" first="K." last="Ogawa">K. Ogawa</name><name sortKey="Sakai, H" sort="Sakai, H" uniqKey="Sakai H" first="H." last="Sakai">H. Sakai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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